MyBioSource.com's SSRP1 Antibody (C-term) is a Rabbit Polyclonal antibody. This antibody has been shown to work in applications such as: ELISA, and Western Blot. The SSRP1 Antibody (C-term) was generated using Hmgi-rs3 as the antigen and it reacts with Human.
Description
The protein encoded by this gene is a subunit of a
heterodimer that, along with SUPT16H, forms chromatin
transcriptional elongation factor FACT. FACT interacts specifically
with histones H2A/H2B to effect nucleosome disassembly and
transcription elongation. FACT and cisplatin-damaged DNA may be
crucial to the anticancer mechanism of cisplatin. This encoded
protein contains a high mobility group box which most likely
constitutes the structure recognition element for
cisplatin-modified DNA. This protein also functions as a
co-activator of the transcriptional activator p63. An alternatively
spliced transcript variant of this gene has been described, but its
full-length nature is not known